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Results for search "Clinical Trials".

Health News Results - 208

Immunotherapy with nivolumab (Opdivo) after surgery for metastatic bladder cancer significantly reduces the odds for the tumor's return, a new clinical trial finds.

Among 700 patients with urothelial cancer of the bladder or other parts of urinary tract that had spread to musc...

Children with Down syndrome are more likely than other kids to have sleep apnea, and existing treatments often fail to work.

Now, an implanted device that stimulates tongue nerves shows promise in reducing their sleep disruptions, a new study finds.

A device called a hypoglossal nerve stimulator is already approved by the U.S. Food and Drug Administration for adults with

  • By Robert Preidt HealthDay Reporter
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  • April 22, 2022
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  • Black Americans are far less likely to be included in clinical trials of pancreatic cancer drugs than white Americans, and eligibility criteria are a significant factor in that gap, according to a new study.

    "The standard of care in cancer treatment is informed by studies conducted with predominantly non-Hispanic white patients," said study author Dr. Jose Trevino, chairman of surgical on...

    An experimental cream-based gene therapy may soon become the first U.S. government-approved means for treating a rare and devastating skin disease that produces "butterfly children."

    Patients with recessive dystrophic epidermolysis bullosa (EB) are called butterfly children "because their skin...

    A new clinical trial strengthens the case that ketamine -- once famous as a club drug -- can rapidly ease suicidal thoughts.

    Researchers found that among 156 adults hospitalized for severe suicidal thoughts, those given two doses of ketamine often saw those disturbing ideas go away within a few days.

    By day three, 63% were in full remission, compared to just under 32% of patients gi...

    A newer type of "clot-busting" medication might be safer than the one long used for treating strokes, a preliminary study hints.

    Researchers found that among nearly 7,900 stroke sufferers, those treated with the drug -- called tenecteplase -- were less likely to suffer life-threatening brain bleeding as a side effect, compared to those given the standard medication alteplase.

    Overal...

    A return to non-contact physical activity three days after a concussion is safe and possibly even beneficial for kids, a Canadian clinical trial finds.

    "Gone are the days of resting in a dark room," said study co-author Andrée-Anne Ledoux, a scientist at the Children's Hospital of Eastern Ontario Research Institute in Ottawa, Canada.

    The

  • Robert Preidt
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  • February 2, 2022
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  • Finding the right medication for rheumatoid arthritis isn't easy, and a newer pill against the disease carries higher risks of heart attack, stroke and cancer than older RA drugs, a new clinical trial confirms.

    The study was mandated by the U.S. Food and Drug Administration after earlier safety signals about the drug, called tofacitinib (Xeljanz).

    In response to the findings, ...

    Saline intravenous (IV) fluids are as effective as more costly solutions in treating intensive care patients and keeping them alive, Australian researchers report.

    "Just about every patient admitted to the intensive care unit (ICU) will receive intravenous fluids for resuscitation or as part of standard treatment," noted

  • Robert Preidt
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  • January 26, 2022
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  • Some kids might be able to get over their peanut allergy if they start immunotherapy while they're still toddlers, a major new clinical trial reports.

    In the trial, a group of 1- to 3-year-olds with severe peanut allergies were safely fed gradually increasing daily doses...

    A drug used to treat several types of cancer is also an effective treatment for aggressive forms of endometrial cancer, the second most common cancer in women worldwide, a new clinical trial shows. The endometrium is the inner lining of the uterus.

    "These findings suggest a long-term benefit to patients," said lead researcher Dr. David O'Malley, a gynecologic oncologist at the Ohio State ...

    For people newly diagnosed with advanced melanoma, a combination of two immunotherapy drugs can double the amount of time their cancer remains progression-free, a clinical trial has found.

    The treatment combines two drugs known as immune checkpoint inhibitors. One, called nivolumab (Opdivo), is already standard for advanced melanoma; the other, relatlimab, is not yet approved.

    But b...

    A medication that acts on certain brain receptors can temporarily ease visual-processing problems in some adults with autism, a small study has found.

    Researchers said it's far too early to know whether the drug, arbaclofen, could prove useful in managing those visual issues. But the findings do give in...

    An international trial found that a once-a-day antiretroviral medication for kids with HIV is not only cheap and easy to take, but also better at suppressing HIV than standard treatments.

    "Our findings provide strong evidence for the global rollout of dolutegravir for children with HIV," said Dr. Diana Gibb, a professor of epidemiology at University College London and a principal investig...

    People undergoing immune-boosting therapy for advanced melanoma may respond better if they eat a high-fiber diet, a new study hints.

    Researchers said much more study is needed, but their initial findings -- in both melanoma patients and lab mice -- suggest that

    They may have other proven health benefits, but new research shows that fish oil supplements don't prevent depression or improve mood.

    Some experts recommend omega-3 fish oil supplements to help prevent depression in high-risk patients, but studies have yielded mixed results and there are no g...

    Two doses of a pediatric Pfizer-BioNTech COVID-19 vaccine failed to spur an adequate immune response in children aged 2 to 5, the companies announced Friday.

    That's a setback for parents hoping to get their youngest children immunized against the new coronavirus as soon as possible.

    The pediatric trials used a 3 microgram (mcg) dose of the vaccine -- equivalent to about one-ten...

    An experimental drug, added to chemotherapy, may benefit women with an aggressive form of breast cancer, suggests an early study offering much-needed good news.

    The study involved women with "triple-negative" breast cancer, which accounts for about 15% to 20% of breast cancers among U.S. women. It is so called because the cancers lack receptors for the hormones estrogen and progesterone, ...

    A gene therapy that could provide a permanent cure for sickle cell disease continues to show success through a third wave of patients, researchers report.

    The therapy, LentiGlobin, restored normal blood function in 35 sickle cell patients who had the one-time procedure, according to clinical trial findings published Dec. 12 in the

  • Dennis Thompson HealthDay Reporter
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  • December 13, 2021
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  • Children with the rare cancer neuroblastoma often succumb to the disease despite aggressive treatment. But researchers have found that adding an experimental antibody to that treatment, right off the bat, may improve their outlook.

    Of 64 children treated with the antibody in a clinical trial, 74% were still alive and free of a recurrence three years later. That compares with historical ra...

    Children with hard-to-control asthma may get relief from adding an injectable antibody drug to their standard treatment, a clinical trial has found.

    The drug, called dupilumab (Dupixent), has been available for several years to treat stubborn asthma in adults and teenagers. Based on the new findings, the

  • Amy Norton HealthDay Reporter
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  • December 9, 2021
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  • U.S. cancer clinical trial participants have become more diverse in makeup, but certain groups remain underrepresented, a new study finds.

    It's important to have a wide range of participants in clinical trials, to find out if treatments are safe and effective for people with different characteristics, according to the National Cancer Institute (NCI), which has a number of initiatives to b...

    A widely available drug used to treat alcoholism has potential as a COVID-19 treatment, researchers say.

    The investigators found that people taking disulfiram (Antabuse) for alcoholism had a lower risk of infection with SARS-CoV-2 and were less likely to die from COVID-19 if infected than those not taking the drug.

  • Robert Preidt
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  • November 23, 2021
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  • Physiotherapist David Putrino was working on a vibrating glove to help deaf people experience live music when a friend mentioned that the same technology might stop tremors in people with Parkinson's disease.

    Putrino, director of rehabilitation innovation for Mount Sinai Health System in New York City, was intrigued. The friend's father had Parkinson's, so they placed the new device on hi...

    Neurologists must make sure Alzheimer's patients and their families understand that the controversial drug aducanumab does not restore mental function, the American Academy of Neurology (AAN) said in new position statement that includes ethical guidelines.

    "Aducanumab is not a cure for Alzheimer's disease, yet since it has been approved by the [U.S. Food and Drug Administration], patients...

    The first human clinical trial of a nasal vaccine to slow the progression of Alzheimer's disease is set to begin after nearly 20 years of research.

    This is a "remarkable milestone," according to Dr. Howard Weiner, co-director of the Ann Romney Center for Neurologic Diseases at Brigham and Women's Hospital in Boston.

    "Over the last two decades, we've amassed preclinical evidence sugg...

    Heart failure patients who fit a specific profile can benefit from injection of stem cells delivered directly into their heart muscle, a new study finds.

    Patients with mild or moderate heart failure who have high levels of inflammation responded well to the stem cell injections, and experienced a decline in their risk of heart attacks, strokes and heart-related death, clinical trial resul...

    COVID-19 vaccines are safe and effective for most cancer patients, a new study confirms.

    Cancer patients have an increased risk of severe illness and death from COVID because their immune systems have been weakened by their disease or treatments.

    "We pursued this study because there were limited data on the safety of SARS-CoV-2 vaccines in people with active cancer; no published pro...

    Illustrating the power of the mind to heal itself, new research suggests that the placebo effect could help drive antidepressants' effects against anxiety disorders.

    The placebo effect refers to an increase in the success of a treatment when a patient expects a benefit.

    In the new study, patients with s...

    An infection that can disable and kill stalks the land, but a brand-new vaccine offers hope that almost everyone, kids included, can evade it. After scientific testing, a nationwide rollout of the vaccine begins.

    Sound familiar?

    As the U.S. government gears up to offer COVID-19 shots to about 28 million 5- to 11-year-olds, high levels of vaccine hesitancy in some corners may make t...

    There are two ways that HIV patients' bodies can keep the virus under control after they stop antiretroviral therapy, a new study shows.

    The findings could point to ways to help people with HIV keep the virus in remission without having to keep taking medications that can have long-term side effects, according to researchers at the U.S. National Institute of Allergy and Infectious Disease...

    After prostate cancer surgery, men can safely undergo fewer radiation treatments at higher doses, a new clinical trial shows.

    Researchers found that the shorter regimen -- given over five weeks, instead of seven -- did not raise patients' odds of lasting side effects.

    Safety has been a "major concern" because when patients have fewer radiation treatments, the daily dose needs to be ...

    High-dose radiation therapy may stall tumor growth in patients with advanced lung cancer who are not fully responding to drug therapies, a preliminary study suggests.

    The study involved patients whose lung cancer was considered "oligoprogressive." That means the cancer had spread to other sites in the body, and the patients were having a mixed response to standard systemic treatments -- i...

    Moderna announced Monday that its COVID-19 vaccine safely triggers a strong immune response in children aged 6 to 11.

    Company data shows that a month after receiving both doses of the vaccine, children's antibody levels were 1.5 ...

    The Pfizer-BioNTech vaccine booster restored close to full protection against COVID-19 in a late-stage trial involving 10,000 people, the company announced Thursday.

    They said the booster was 95.6% effective and that they plan to submit the latest data to the U.S. Food and Drug Administration and regulators in other nations.

    "These results provide further evidence of the benefits of...

    Men still outnumber women in stroke therapy clinical trials, which means women may end up receiving less effective treatment, researchers say.

    For the new study, investigators analyzed 281 stroke trials that included at least 100 patients each and were conducted between 1990 and 2020.

    Of the nearly 590,000 total participants, 37.4% were women. However, the average rate of stroke amo...

    A new study confirms that fish oil supplements may raise the risk of a common heart-rhythm disorder -- particularly when doses top 1 gram per day.

    At issue are medications and supplements containing omega-3 fatty acids, which are naturally found in fish oil.

    Fish is considered a generally heart-healthy food, but some studies have linked omega-3 in capsule form to an increased risk o...

    Patients who undergo surgery for certain types of cancer may have better short-term survival if they receive a particular anti-nausea drug, a preliminary study suggests.

    Among more than 74,000 patients who had cancer surgery, researchers found that those who received the drug -- called dexamethasone -- were less likely to die in the next 90 days.

    The vast majority of all patients su...

    A drug previously approved for multiple sclerosis also can treat inflammatory bowel disease in some patients, a new clinical trial reports.

    The medication, ozanimod (Zeposia), proved effective in helping patients with ulcerative colitis, sending many into full remission, according to results being published Sept. 30 in the New England Journal of Medicine.

    Ulcerative colitis...

    If you have cancer and you think coronavirus vaccines may do you little good, don't let your hesitation stop you from getting the shots: A pair of clinical trials finds that patients' immune systems ramped up after vaccination.

    The findings were presented this week during a virtual meeting of the European Society for Medical Oncology (ESMO Congress 2021).

    "We have to vaccinate all o...

    New research offers good news for women with an aggressive HER2-positive breast cancer.

    A targeted therapy, trastuzumab deruxtecan (T-DXd), sold as Enhertu, triples the length of time that the cancer remains in check when compared with the current gold standard, trastuzumab emtansine (T-DM1).

    Both of these drugs are second-line treatment options for HER2-positive breast cancer that ...

    FRIDAY, Sept. 17, 2021 (HealthDay News) -- Researchers hoped to show that the natural antioxidant urate could delay Parkinson's disease progression, but a study completed at Massachusetts General Hospital dashed those expectations.

    The trial enrolled nearly 300 individuals recently diagnosed with early Parkinson's disease, which affects the body's motor system. Symptoms such as tremors,...

    An experimental Ebola vaccine appeared effective in children and adults in a clinical trial.

    Two doses of Johnson & Johnson's Ebola vaccine appear safe, well tolerated and produce a strong immune response in people over the age of 1, according to two just-published papers.

    ...

    COVID-19 vaccine booster shots might not be needed for most people, according to a large international review.

    The review -- conducted by a team that included scientists from the World Health Organization and the U.S. Food and Drug Administration -- concluded that current vaccines are effective enough against severe COVID-19, even from the Delta variant, and that booster shots are unnece...

    A drug that lowers cholesterol might help save hospitalized patients with COVID-19, a new, small Israeli study suggests.

    Researchers at Hebrew University of Jerusalem noted that COVID causes a big buildup of cholesterol, which results in inflammation in cells.

    In lab experiments, they found that the cholesterol-lowering drug fenofibrate (TriCor) effectively reduced damage to lung ce...

    A new approach to spinal cord stimulation may drastically reduce chronic back pain, a small pilot study suggests.

    The study, of 20 patients with stubborn low back pain, tested the effects of implanting electrodes near the spinal cord to stimulate it with "ultra-low" frequency electrical pulses.

    After two weeks, 90% of the patients were reporting at least an 80% reduction in their pa...

    A new pill specifically designed to prevent migraines appears to do the job, a new clinical trial finds.

    Atogepant cut patients' migraine days in half over 12 weeks of treatment, without causing serious side effects, the researchers said.

    Experts said the drug, if approved by the U.S. Food and Drug Administration, would give migraine sufferers a welcome new option.

    "There's a ...

    Racial and ethnic minorities in the United States are severely underrepresented in clinical trials testing cutting-edge treatments for pancreatic cancer, researchers say.

    "There are a ton of obstacles to get these patients into clinical trials," said senior author Dr. Jose Trevino, chairman of surgical oncology at Virginia Commonwealth University School of Medicine. "But this is how we're...

    An experimental gel has shown early promise in treating the most common form of skin cancer -- hinting at a potential alternative to surgery in the future.

    Researchers tested the gel in 30 patients with basal cell carcinoma (BCC), a skin cancer diagnosed in more than 3 million Americans each year. The tumors rarely spread and are highly curable, usually through surgical removal.

    Eve...

    The pandemic widely disrupted medical care across the United States, but a new study reports that clinical trials testing cancer treatments were able to carry on.

    Researchers found that U.S. cancer trials quickly responded to the pandemic in the early months, allowing the studies to get back on track after an initial -- and steep -- drop-off in patient participation.

    That was partic...