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Results for search "Clinical Trials".

Health News Results - 83

The newly approved drug teprotumumab can offer hope to adults with thyroid eye disease, a rare and potentially blinding condition.

It's the first treatment specifically approved for thyroid eye disease. The drug was approved Tuesday by the U.S. Food and Drug Administration. It will be marketed under the brand name Tepezza.

"This may be a drug that offers a new approach and ...

A new gene therapy appears to serve as a functional cure for the most common type of hemophilia, early clinical trial results indicate.

Patients who received the one-time intravenous therapy continue to have a more than 90% decrease in bleeding events two to three years after their initial treatment, researchers reported Jan. 1 in the New England Journal of Medicine.

...

An experimental Zika virus vaccine that was given before pregnancy protected monkey fetuses, researchers say.

The Zika DNA vaccine VRC5283 lowered levels of Zika virus in pregnant rhesus macaques and reduced the risk of fetal problems, according to the study published Dec. 18 in the journal Science Translational Medicine.

The vaccine is in early-stage human trials.

Male researchers are far more likely than female colleagues to claim that their findings are especially important, a new study says.

The language used to describe discoveries can affect how much attention researchers get and also affect their career advancement. These findings may help explain why women in medicine and science tend to get paid less and have fewer career opportunities,...

A drug used to fight chronic myeloid leukemia might also relieve symptoms of Parkinson's disease, a new study finds.

In a phase 2 clinical trial, researchers found that the drug nilotinib (brand name: Tasigna) increased production of dopamine and halted decline in motor function. It was well-tolerated by most participants.

"We found that nilotinib is reasonably safe using d...

A treatment that delivers ultrasound waves to the brain may bring lasting relief to some people with debilitating hand tremors, a new study finds.

The study involved 76 patients with essential tremor -- a neurological condition that most often causes trembling in the hands during routine tasks like writing, eating and dressing. It can also affect the legs, head, trunk or voice.

...

People with peanut allergy must be constantly vigilant to avoid a life-threatening allergic reaction. But researchers report that a new drug injection might offer at least temporary protection against the most severe reactions.

Just one shot of an experimental antibody treatment allowed people with severe peanut allergy to eat about one peanut's worth of peanut protein two weeks late...

A three-drug combo that significantly improves lung function in cystic fibrosis patients could benefit 90% of people with the life-threatening disease, a new study suggests.

It included patients with a single copy of the most common genetic mutation for the disease.

Results of the international phase 3 clinical trial led the U.S. Food and Drug Administration to approve ...

Fecal transplants can bring the promise of an improved microbiome in ill patients, but a new report suggests they are not risk-free.

In a fecal transplant, donated fecal matter is processed and put into capsules for patients to swallow. Once in the gut, the capsules dissolve, releasing new, healthy bacteria into the gut.

But doctors from Massachusetts General Hospital in B...

Computer-driven artificial intelligence (AI) can help protect human brains from the damage wrought by stroke, a new report suggests.

A computer program trained to look for bleeding in the brain outperformed two of four certified radiologists, finding abnormalities in brain scans quickly and efficiently, the researchers reported.

"This AI can evaluate the whole head in one se...

A new drug to treat most cystic fibrosis patients has been approved by the U.S. Food and Drug Administration.

Trikafta (elexacaftor/ivacaftor/tezacaftor) is the first triple combination therapy available to treat patients with the most common cystic fibrosis mutation. Its list price is $311,000 a year, same as one of the maker's earlier treatments for the genetic disease.

Tr...

For people with gastroesophageal reflux disease (GERD) that doesn't respond to the usual treatments, a complex surgery may help, a new study finds.

In carefully selected patients, the surgery provided much more relief than two different types of medication treatment -- 67% for surgery compared to 28% for "active" drug treatment and 12% for the "control" (placebo) drug tre...

A new 3-in-1 asthma drug inhaler may provide better and easier control of symptoms for tough-to-treat patients, two new studies suggest.

The two phase 3 trials involved more than 2,500 asthma patients across 17 countries. Patients tested out an inhaler that contained three drugs: A steroid preventer to control inflammation; a long-acting bronchodilator to keep airways open; and a drug...

Chinese researchers may deserve a toast for their new findings that suggest light to moderate drinking may be beneficial for people with type 2 diabetes.

The review found that people who had a bit of alcohol daily had lower levels of a type of blood fat called triglycerides. But alcohol didn't seem to lower blood sugar levels in people who already had type 2 diabetes, the review found...

Ten cancer drugs being tested in human clinical trials appear to work -- but not in the ways their developers thought they would, researchers say.

"The idea for many of these drugs is that they block the function of a certain protein in cancer cells. And what we showed is that most of these drugs don't work by blocking the function of the protein that they were reported to block," sa...

Estrogen therapy may help younger women live longer after having their uterus and ovaries surgically removed, new research reports.

The study found that when women under 60 received hormone replacement therapy (HRT) after surgery, their risk of dying during the 18-year follow-up period decreased by almost one-third compared to women taking a placebo.

"In a young woman, it'...

Antidepressants typically take four to eight weeks to ease the debilitating symptoms of depression, but an early clinical trial found a new type of drug brought relief in just two weeks.

"SAGE-217, once fully developed, has potential to offer relatively quick and clinically meaningful alleviation of depressive symptoms in patients with moderate to severe major depressive disorder," sa...

Opening all of a person's clogged arteries after a heart attack can protect their health better than reopening only the one that caused it, a major international clinical trial has concluded.

Opening all blockages and not just the "culprit" behind the attack reduces a patient's risk of dying or having another heart attack by 26%, researchers reported Se...

A vaccine against the sexually transmitted disease chlamydia appears safe and potentially effective, an early trial suggests.

The phase 1 study included 35 healthy women. Those who were given injections of two possible vaccines developed antibodies to the chlamydia bacteria, but a lot more testing is needed before the vaccine would be ready for the public, the researchers added.

...

Summary results of clinical trials published in top journals are often exaggerated, a new review charges.

The review says such spin -- exaggerating the clinical significance of a treatment without statistics to back it up -- is common in abstracts published in leading psychology and psychiatry journals. And the authors warn it could be dangerous, because the abstracts could affect doc...

Green tea is a popular health trend, with many people sipping it in hopes of deriving benefits from the brew.

There's nothing wrong with that, dietitians say -- green tea is a healthy drink loaded with antioxidants. But the jury's still out on many of its purported health benefits.

"Clinical trials related to green tea are still in their early stages," said Nancy Farrell All...

Glioblastoma brain cancer remains one of deadliest tumors, and new research shows five-year survival rates remain low for patients with the disease.

While there have been improvements in short- and medium-term survival rates for patients with the most common type of brain tumor in adults, only 6% of patients live for five years after diagnosis, according to the Mayo Clinic researc...

Treatment with blood pressure medication can improve blood flow to a key brain region in people with Alzheimer's disease, a small clinical trial has found.

Researchers stressed that they do not know whether the brain finding can translate into any benefits for patients. But future studies should look into that possibility, they said.

The findings, published June 17 in the jo...

A two-year delay in the onset of type 1 diabetes could make a big difference for people with the disease. And researchers say a new drug may make that postponement possible.

Researchers gave the drug teplizumab or a placebo to a small group of people who were nearly certain to develop type 1 diabetes, based on genetics and certain symptoms. Those given a placebo, or dummy drug, progre...

Cutting-edge prostate cancer drugs that help extend life in the toughest cases might also be useful in fighting less aggressive tumors, two new clinical trials suggest.

Two drugs that interfere with cancer's ability to use testosterone for fuel, apalutamide (Erleada) and enzalutamide (Xtandi), are already approved for use against more advanced prostate tumo...

Medical marijuana extracts appear to help children with autism, reducing their disruptive behavior while improving their social responsiveness, a new Israeli clinical trial reports.

Kids treated with either a whole-plant cannabis extract or a pure combination of cannabidiol (CBD) and THC experienced a significant improvement in their symptoms, compared with a control group given a place...

Hormone-based treatment might improve social function in people with autism, a pair of new clinical trials suggests.

Both focused on vasopressin, a hormone that has been implicated in the brain's ability to manage social behavior.

In the first trial, vasopressin given as a nasal spray helped improve social responsiveness in kids with autism, said lead researcher Karen Parker...

The idea behind immunotherapy for peanut allergy is appealing in its simplicity: Ask a patient to eat tiny amounts of peanut every day, and over time their immune system will become desensitized to it.

Unfortunately, this cure might be doing more harm than the allergy itself, a new evidence review suggests.

People who undergo immunotherapy for their peanut allergies wind up with...

Researchers say an experimental stroke drug prevented blood clots without the typical side effect of blood thinners: increased bleeding risk.

Bleeding is a common and potentially dangerous side effect of current anti-clotting drugs used to treat stroke patients. But the new findings suggest that the antiplatelet drug, called ACT017, may be a safe and effective alternative to current t...

Danish researchers have sniffed out a potential new weapon to fight armpit odor.

It's zinc oxide, or ZnO. The strategy was inspired by hospital wound care. Because putting zinc oxide on open surgical wounds reduces corynebacteria and the bad smell it creates, researchers thought it might also make an effective deodorant.

The study authors said their small, early trial with 3...

A new method of brewing a cancer vaccine inside a patient's tumor could harness the power of the immune system to destroy the disease, researchers report.

Immune stimulants are injected directly into a tumor, which teaches the immune system to recognize and destroy all similar cancer cells throughout the body, said senior researcher Dr. Joshua Brody. He is director of the Lymph...

Blood vessels created in the lab can successfully turn into "living tissue" in patients on dialysis for advanced kidney disease, a new study suggests.

The results come from just 13 patients in an early-phase trial. But researchers said they are a sign that the engineered tissue might eventually offer new treatment options for patients with damaged blood vessels -- due to conditions rang...

Precious few treatment guidelines for heart patients are supported by the best scientific evidence, a new study shows.

Less than one in 10 recommendations are based on results from multiple randomized controlled trials (considered the "gold standard"), and that percentage has actually dropped in the past decade, the researchers reported.

For the study, the investigators anal...

People whose high cholesterol is resistant to treatment with statin drugs may soon have a new treatment option.

This new class of drugs helps block synthesis of artery-clogging cholesterol, researchers explained. The drugs target an enzyme called ATP citrate lyase (ACL), part of the production pathway for "bad" LDL cholesterol in the body.

In the new trial, bempedoic acid, a pil...

For people with the deadly skin cancer melanoma, one dose of the drug Keytruda before surgery might stop the cancer in its tracks, according to a groundbreaking new study.

Keytruda (pembrolizumab) is a PD-1 inhibitor, an immunotherapy drug that triggers the body's immune response to attack cancer cells. According to results of this study, the drug's effects peak as early as seven days...

People who are paid to take part in research may be more likely to lie about their eligibility than those who aren't paid, a new study finds.

It included nearly 2,300 people who were surveyed on whether they're received a recent flu shot. One group of participants was told that their eligibility to take part in the survey didn't depend on whether or not they'd had a flu shot. This was...

An experimental drug has shown promise in extending the lives of women suffering from a particularly aggressive and deadly type of breast cancer, according to the results of a phase 2 trial.

Right now, the standard treatment of chemotherapy for metastatic triple-negative breast cancer has not been very effective. That might change with the new drug, called sacituzumab govitecan, whic...

Instead of popping a painkiller, a little mindful yoga might go a long way toward easing longstanding pain, a new study suggests.

The review of 21 clinical trials involving nearly 2,000 people looked at the effects of two drug-free options for chronic pain: cognitive behavioral therapy (CBT) and a program called mindfulness-based stress reduction (MBSR). It combines meditation and gen...

Cholesterol-lowering statins are already known to help cut heart risks for seniors and the middle-aged. Now, research confirms the meds can also help people aged 75 and older.

"Statin therapy has been shown to prevent cardiovascular disease in a wide range of people, but there has been uncertainty about its efficacy and safety among older people," said lead investigator Anthony Keech...

A stem cell transplant may help some people with multiple sclerosis (MS) when standard drugs fail, a new clinical trial finds.

The study focused on 110 patients with aggressive cases of MS: Their symptoms had flared up at least twice in the past year despite taking standard medication, and they'd already tried an average of three of those drugs.

Researchers randomly assigned...

Drug approvals for adults often require future studies in children, but many of these studies are never completed, a new analysis finds.

"More than 50 percent of all drugs approved by the FDA lack information on how to safely and effectively use the drug in children," said study author Dr. Florence Bourgeois, from the Pediatric Therapeutics and Regulatory Science Initiative at Boston ...

People with celiac disease must follow a very restrictive diet, but an experimental vaccine may offer many of them the freedom to eat more normally.

Celiac disease is an autoimmune disorder. If someone with the disease eats gluten -- a protein found in wheat, barley and rye -- it can damage the small intestine.

The vaccine, dubbed Nexvax2, is designed to elicit an immune sy...

Untreatable, antibiotic-resistant gonorrhea has become a chilling prospect in the United States, raising concerns that people might someday have to live with the sexually transmitted bacteria.

But now there's reason for hope. A newly developed antibiotic pill has proven effective against gonorrhea in early clinical trials.

Zoliflodacin proved effective in treating gonorrhea ...

The first Food and Drug Administration-approved drug containing an ingredient derived from the marijuana plant went on sale Thursday in the United States.

Epidiolex is a twice-daily oral solution -- a cannabidiol, or CBD liquid -- made by Britain-based GW Pharmaceuticals. It is approved for use in patients 2 years old and older with two types of epileptic syndromes, Dravet syndrome an...

An experimental vaginal ring meant to prevent pregnancy and HIV looks safe, according to an early stage study.

The dual-purpose ring releases the antiretroviral drug dapivirine and the contraceptive hormone levonorgestrel, said researchers led by Dr. Sharon Achilles, of the University of Pittsburgh School of Medicine.

"We are very encouraged by our findings in this first-in...

A new gene therapy might help improve motor symptoms in people with Parkinson's disease who aren't responding to other therapies, an early study has found.

"This is not a cure of Parkinson's disease," said James Beck, chief scientific officer of the Parkinson's Foundation. "This is a potentially good treatment for symptom control. It provides an additional way of providing dopamine t...

In what researchers are calling a "breakthrough," two preliminary trials have found that either of two triple-drug regimens could potentially benefit 90 percent of people with cystic fibrosis.

The trials were short-term, finding that the drug combinations improved adult patients' lung function over four weeks. But experts said they were optimistic the results will hold up in the large...

A personalized vaccine held an aggressive group of cancers in check among more than half of patients who received it in a small, preliminary trial, researchers report.

HER2-positive cancers are cancers that have too much of the HER2 protein on their surface. In that setting, a cancer can grow rapidly and be more likely to spread to other areas of the body. Areas known to have HER2-pos...

A combination of two HIV-fighting antibodies can suppress the virus in some patients, even after they stop standard drugs, a preliminary trial has shown.

Researchers found that among 11 HIV patients given the antibody combo, nine maintained complete suppression of the virus after going off their medication regimen. The benefit typically lasted about five months.

The hope, ex...

Thousands of Americans struggling with chronic obstructive pulmonary disease (COPD) may have a new treatment option to help them breathe easier.

COPD, which is often linked to smoking, is a progressive deterioration of lung function that involves a combination of bronchitis and emphysema symptoms. It's the third leading cause of death in the United States, and while treatments can eas...