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Results for search "Clinical Trials".

Health News Results - 92

Intensive high blood pressure treatment may protect against a-fib, a heart rhythm disorder that can lead to stroke, heart attack and heart failure, researchers say.

They analyzed data from more than 8,000 high blood pressure patients who were at increased risk of heart disease and enrolled in a U.S. National Institutes of Health trial known as SPRINT.

Participants were on e...

In the race to find treatments for COVID-19, the antiviral drug remdesivir has gotten much of the attention. But researchers say a class of long-used drugs called interferons also looks promising.

Trials testing the medications are underway in several countries. A small study published last week in The Lancet found that a three-drug regimen, containing an interferon, helped hos...

A combination of chemotherapy and immunotherapy may slow the progress of metastatic bladder cancer and extend survival, a clinical trial suggests.

Current treatment for advanced bladder cancer is chemotherapy, but adding the immunotherapy drug atezolizumab (Tecentriq) appears to help more patients fight this disease. It strikes 81,000 Americans a year and kills 18,000.

"Th...

There's been much speculation about whether vitamin D might prevent or help survival with COVID-19, and two new studies appear to underscore the link.

In the first study -- published in the journal Aging Clinical and Experimental Research -- British researchers found that COVID-19 infections and deaths were higher in countries where people had low vitamin D levels, such as Ita...

In the scramble to find medicines that beat back COVID-19, researchers from Italy report encouraging results from a small study on a rheumatoid arthritis drug already in use.

The drug, anakinra, may help quiet the runaway immune response known as a "cytokine storm," which imperils some patients with severe COVID-19.

"Until a vaccine is available, we urgently need to find a w...

There's been a sharp decline in the number of U.S. children taking part in cancer clinical trials over the past few decades, but researchers say that might be good news.

Why? Having more effective treatments available now may be one reason for that decrease, they explained.

The researchers, from the University of Colorado Cancer Center, analyzed national data and found that ...

Researchers have reformulated an HIV medication into a version they hope can eventually be taken as infrequently as once a year.

The work is only in the early stages, having been studied in lab animals. But the goal is to create an HIV drug that can be injected annually -- offering protection from infection or control of the virus in people who already have it.

The researche...

A new oral polio vaccine promises to help make polio a disease of the past, according to the results of a phase 1 clinical trial.

Polio was almost eliminated worldwide -- except in vaccine-induced cases. In those cases, the weakened virus used in vaccines developed the ability to escape from immunized individuals and spread in places with low vaccination rates.

The new des...

Dozens of drugs are being investigated for their value in treating COVID-19, as desperation drives doctors and researchers to look for something that could battle the virus and save lives.

"There are really no FDA-approved medications for the treatment of COVID-19, unfortunately," said Ashley Barlow, a pharmacy resident with the University of Maryland Medical Center in Baltimore. "We'...

As researchers hunt for ways to treat severe COVID-19 infections, a new trial will ask whether an old arthritis drug can prevent serious complications in the first place.

The medication, called colchicine, is an oral anti-inflammatory that has long been prescribed for gout, a form of arthritis. Its history goes back thousands of years, and the drug was first sourced from the autumn cr...

Preliminary data from two clinical trials using the antiviral drug remdesivir to treat COVID-19 patients is encouraging, researchers report.

One trial is providing the drug to patients with moderate illness and the other focuses on patients with severe illness.

A number of the patients are now recovering and have been released from the hospital. While it's too early to tell...

Doctors at the University of Alabama at Birmingham (UAB) are enrolling patients in an international clinical trial to find out if inhaled nitric oxide benefits those with COVID-19 who have severely damaged lungs.

Right now, there are no approved treatments for the illness caused by the new coronavirus. A severe form of lung failure called acute respiratory distress syndrome is the lea...

Intensifying a standard form of brain stimulation may bring relief to people with hard-to-treat depression, a preliminary study suggests.

The study involved just 21 patients, but the treatment sent 90% into remission within a few days. That's a success rate that has never been seen in early testing of other therapies for severe depression, the researchers said.

The thera...

A drug originally developed to treat Ebola is getting a second chance in the spotlight, as research teams in the United States, Asia and Europe race to test it against the new coronavirus.

The drug, called remdesivir, has already been given to a limited number of patients hospitalized with COVID-19, on a "compassionate use" basis. That included the first U.S. patient diagnosed with th...

The first community-acquired case of COVID-19 in the United States posed many questions for doctors, but the answers they found led to key changes in federal guidelines for coronavirus testing, according to a case study.

The patient was an otherwise healthy woman in her 40s who was admitted to University of California (UC) Davis Health with a respiratory infection. Doctors suspected c...

Millions of Americans pop a low-dose aspirin each day to help ward off heart issues, but a new study finds that protection may not extend to dementia.

Although the anti-inflammatory effects of aspirin have been touted as protection against thinking and memory (or "cognitive") problems from Alzheimer's and other dementias, a large, randomized trial suggests aspirin won't slow mental de...

Racial bias and stereotyping are common when researchers are recruiting people for cancer clinical trials, a new study finds.

"Examples of the stereotypes we observed included perceptions that African Americans were less knowledgeable about cancer research studies, less likely to participate due to altruism, or simply less likely to complete all facets of the research study," said stu...

Most clinical trial participants are not told the results of their study -- even though most people want to know, and researchers want to tell them.

The reason: Communication is a big barrier, a new study says. Simply put, researchers and subjects may not speak the same language.

Teaching researchers to make their findings understandable to the lay person could make trial p...

While the world's focus is trained on the new coronavirus, a groundbreaking clinical trial finds researchers battling a tough-to-treat form of an "old" infectious disease, tuberculosis.

TB is a bacterial infection that usually attacks the lungs. The disease does not get much attention in wealthy nations, where it's less common. The United States saw about 9,000 cases in 2018, accordin...

The immunotherapy drug Keytruda might offer a new treatment option to women with an aggressive form of breast cancer, a clinical trial suggests.

The study found that for women with "triple-negative" breast cancer, adding Keytruda to standard chemotherapy improved their odds of responding.

And in the months afterward, women treated with the drug were less likely to see their ...

The best available drugs to treat sudden COPD flare-ups are the medications already widely in use, antibiotics and corticosteroids, a new evidence review has concluded.

There's not enough evidence to recommend newer treatments for chronic obstructive pulmonary disease (COPD), said lead researcher Dr. Claudia Dobler, a visiting scholar at the Mayo Clinic in Rochester, Minn.

S...

Women remain underrepresented in heart disease research, even though it's the leading cause of death among women worldwide, researchers say.

Women accounted for less than 40% of all people enrolled in cardiovascular clinical trials from 2010 through 2017, according to a study published Feb. 17 in the journal Circulation.

"One woman dies from cardiovascular disease...

In a first, scientists have used gene-editing technology to create "designer" immune system cells that can fight tumors and survive for months in cancer patients' bodies.

It's a proof of principle, the researchers say -- and an early step toward bringing the gene-editing tool known as CRISPR into cancer treatment.

CRISPR allows researchers to precisely "snip" bits of DNA wit...

Most people take the ability to move for granted, but not Kathy Miska.

Miska has had multiple sclerosis for two decades now, and her ability to get around has deteriorated steadily.

Now, a new robotic exoskeleton is giving her an opportunity to regain some of the mobility she's lost to the degenerative nerve disease.

"You can definitely tell when you get out of the suit....

Enrollment in clinical trials that can potentially extend the life of cancer patients is too low, a new study finds.

Researchers at Penn State also found that white males with private health insurance and cancers that have spread, and who are treated at academic medical centers, are most likely to enroll in clinical trials.

Lead researcher Dr. Nicholas Zaorsky, of Penn Sta...

The newly approved drug teprotumumab can offer hope to adults with thyroid eye disease, a rare and potentially blinding condition.

It's the first treatment specifically approved for thyroid eye disease. The drug was approved Tuesday by the U.S. Food and Drug Administration. It will be marketed under the brand name Tepezza.

"This may be a drug that offers a new approach and ...

A new gene therapy appears to serve as a functional cure for the most common type of hemophilia, early clinical trial results indicate.

Patients who received the one-time intravenous therapy continue to have a more than 90% decrease in bleeding events two to three years after their initial treatment, researchers reported Jan. 1 in the New England Journal of Medicine.

...

An experimental Zika virus vaccine that was given before pregnancy protected monkey fetuses, researchers say.

The Zika DNA vaccine VRC5283 lowered levels of Zika virus in pregnant rhesus macaques and reduced the risk of fetal problems, according to the study published Dec. 18 in the journal Science Translational Medicine.

The vaccine is in early-stage human trials.

Male researchers are far more likely than female colleagues to claim that their findings are especially important, a new study says.

The language used to describe discoveries can affect how much attention researchers get and also affect their career advancement. These findings may help explain why women in medicine and science tend to get paid less and have fewer career opportunities,...

A drug used to fight chronic myeloid leukemia might also relieve symptoms of Parkinson's disease, a new study finds.

In a phase 2 clinical trial, researchers found that the drug nilotinib (brand name: Tasigna) increased production of dopamine and halted decline in motor function. It was well-tolerated by most participants.

"We found that nilotinib is reasonably safe using d...

A treatment that delivers ultrasound waves to the brain may bring lasting relief to some people with debilitating hand tremors, a new study finds.

The study involved 76 patients with essential tremor -- a neurological condition that most often causes trembling in the hands during routine tasks like writing, eating and dressing. It can also affect the legs, head, trunk or voice.

...

People with peanut allergy must be constantly vigilant to avoid a life-threatening allergic reaction. But researchers report that a new drug injection might offer at least temporary protection against the most severe reactions.

Just one shot of an experimental antibody treatment allowed people with severe peanut allergy to eat about one peanut's worth of peanut protein two weeks late...

A three-drug combo that significantly improves lung function in cystic fibrosis patients could benefit 90% of people with the life-threatening disease, a new study suggests.

It included patients with a single copy of the most common genetic mutation for the disease.

Results of the international phase 3 clinical trial led the U.S. Food and Drug Administration to approve ...

Fecal transplants can bring the promise of an improved microbiome in ill patients, but a new report suggests they are not risk-free.

In a fecal transplant, donated fecal matter is processed and put into capsules for patients to swallow. Once in the gut, the capsules dissolve, releasing new, healthy bacteria into the gut.

But doctors from Massachusetts General Hospital in B...

Computer-driven artificial intelligence (AI) can help protect human brains from the damage wrought by stroke, a new report suggests.

A computer program trained to look for bleeding in the brain outperformed two of four certified radiologists, finding abnormalities in brain scans quickly and efficiently, the researchers reported.

"This AI can evaluate the whole head in one se...

A new drug to treat most cystic fibrosis patients has been approved by the U.S. Food and Drug Administration.

Trikafta (elexacaftor/ivacaftor/tezacaftor) is the first triple combination therapy available to treat patients with the most common cystic fibrosis mutation. Its list price is $311,000 a year, same as one of the maker's earlier treatments for the genetic disease.

Tr...

For people with gastroesophageal reflux disease (GERD) that doesn't respond to the usual treatments, a complex surgery may help, a new study finds.

In carefully selected patients, the surgery provided much more relief than two different types of medication treatment -- 67% for surgery compared to 28% for "active" drug treatment and 12% for the "control" (placebo) drug tre...

A new 3-in-1 asthma drug inhaler may provide better and easier control of symptoms for tough-to-treat patients, two new studies suggest.

The two phase 3 trials involved more than 2,500 asthma patients across 17 countries. Patients tested out an inhaler that contained three drugs: A steroid preventer to control inflammation; a long-acting bronchodilator to keep airways open; and a drug...

Chinese researchers may deserve a toast for their new findings that suggest light to moderate drinking may be beneficial for people with type 2 diabetes.

The review found that people who had a bit of alcohol daily had lower levels of a type of blood fat called triglycerides. But alcohol didn't seem to lower blood sugar levels in people who already had type 2 diabetes, the review found...

Ten cancer drugs being tested in human clinical trials appear to work -- but not in the ways their developers thought they would, researchers say.

"The idea for many of these drugs is that they block the function of a certain protein in cancer cells. And what we showed is that most of these drugs don't work by blocking the function of the protein that they were reported to block," sa...

Estrogen therapy may help younger women live longer after having their uterus and ovaries surgically removed, new research reports.

The study found that when women under 60 received hormone replacement therapy (HRT) after surgery, their risk of dying during the 18-year follow-up period decreased by almost one-third compared to women taking a placebo.

"In a young woman, it'...

Antidepressants typically take four to eight weeks to ease the debilitating symptoms of depression, but an early clinical trial found a new type of drug brought relief in just two weeks.

"SAGE-217, once fully developed, has potential to offer relatively quick and clinically meaningful alleviation of depressive symptoms in patients with moderate to severe major depressive disorder," sa...

Opening all of a person's clogged arteries after a heart attack can protect their health better than reopening only the one that caused it, a major international clinical trial has concluded.

Opening all blockages and not just the "culprit" behind the attack reduces a patient's risk of dying or having another heart attack by 26%, researchers reported Se...

A vaccine against the sexually transmitted disease chlamydia appears safe and potentially effective, an early trial suggests.

The phase 1 study included 35 healthy women. Those who were given injections of two possible vaccines developed antibodies to the chlamydia bacteria, but a lot more testing is needed before the vaccine would be ready for the public, the researchers added.

...

Summary results of clinical trials published in top journals are often exaggerated, a new review charges.

The review says such spin -- exaggerating the clinical significance of a treatment without statistics to back it up -- is common in abstracts published in leading psychology and psychiatry journals. And the authors warn it could be dangerous, because the abstracts could affect doc...

Green tea is a popular health trend, with many people sipping it in hopes of deriving benefits from the brew.

There's nothing wrong with that, dietitians say -- green tea is a healthy drink loaded with antioxidants. But the jury's still out on many of its purported health benefits.

"Clinical trials related to green tea are still in their early stages," said Nancy Farrell All...

Glioblastoma brain cancer remains one of deadliest tumors, and new research shows five-year survival rates remain low for patients with the disease.

While there have been improvements in short- and medium-term survival rates for patients with the most common type of brain tumor in adults, only 6% of patients live for five years after diagnosis, according to the Mayo Clinic researc...

Treatment with blood pressure medication can improve blood flow to a key brain region in people with Alzheimer's disease, a small clinical trial has found.

Researchers stressed that they do not know whether the brain finding can translate into any benefits for patients. But future studies should look into that possibility, they said.

The findings, published June 17 in the jo...

A two-year delay in the onset of type 1 diabetes could make a big difference for people with the disease. And researchers say a new drug may make that postponement possible.

Researchers gave the drug teplizumab or a placebo to a small group of people who were nearly certain to develop type 1 diabetes, based on genetics and certain symptoms. Those given a placebo, or dummy drug, progre...

Cutting-edge prostate cancer drugs that help extend life in the toughest cases might also be useful in fighting less aggressive tumors, two new clinical trials suggest.

Two drugs that interfere with cancer's ability to use testosterone for fuel, apalutamide (Erleada) and enzalutamide (Xtandi), are already approved for use against more advanced prostate tumo...