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Results for search "Clinical Trials".

Health News Results - 116

A widely used tuberculosis vaccine may help protect people against the new coronavirus or reduce the severity of COVID-19, a new study suggests.

The Bacillus Calmette-Guérin (BCG) was developed in the early 1900s and is given to more than 100 million children worldwide every year.

In the United States, BCG is approved as a vaccine for people at high risk of contracting tuberculosis...

Children should be included in COVID-19 vaccine trials at the earliest possible stage, a leading group of U.S. pediatricians says.

If that's not done, youngsters' lives could be at risk, according to the 67,000-member American Academy of Pediatrics (AAP).

"If we do not add children to these research trials very soon, there will be a significant delay in when children are able to ac...

A procedure that "stuns" pain-sensing nerves might offer relief to people with severe arthritis of the hip or shoulder, a small, preliminary study suggests.

The procedure is a form of radiofrequency ablation, where doctors use needles to send a low-grade electrical current to nerves that are transmitting pain signals from the arthritic joint to the brain. The current heats and damages the...

A Chinese COVID-19 vaccine seems to be safe and effective, early trial results suggest, but one expert says the findings should be regarded with caution.

The CoronaVac vaccine is based on inactivated SARS-CoV-2 virus. It was tested in a phase 1/2 clinical trial that included more than 700 healthy volunteers, ages 18-59, who were recruited in China between April 16 and May 5.

The vac...

A combination of two "targeted" therapies can beat back a rare form of blood cancer -- without the toxic effects of chemotherapy, a new study has found.

In a trial of 63 patients, researchers found that the drug regimen frequently wiped out all signs of the cancer -- a subtype of the blood cancer acute lymphoblastic leukemia (ALL). And at 18 months, 95% of patients were still aliv...

A recently approved rheumatoid arthritis medication appears to be an effective second-line therapy when biologic treatments start to fail, a new clinical trial reports.

Arthritis sufferers treated with upadacitinib had a significantly greater reduction in their symptoms and disease activity than people treated with a standard disease-modifying antirheumatic drug (DMARD), said co-resea...

An experimental drug combination lengthens survival for patients with amyotrophic lateral sclerosis (ALS), new research shows.

A previous clinical trial found that the two-drug combo -- called AMX0035 -- slowed progression of the neurodegenerative disease over six months.

The new clinical trial of 137 patients with the disease, also known as Lou Gehrig's disease, found that ...

A small study suggests that a new procedure that treats part of the intestine just beyond the stomach may allow people with type 2 diabetes to safely stop taking insulin.

The procedure -- which resurfaces the duodenum -- was combined with a popular kind of diabetes medication called GLP-1 receptor agonists (such as Victoza, Trulicity, Ozempic) and counseling on lifestyle factors, such a...

Type 2 diabetes can be tough to control without medication. But for some people, the thought of daily shots makes them delay or avoid starting insulin therapy.

Now, new research offers some hope for those insulin avoiders -- a once-a-week insulin injection may someday replace daily shots.

A phase 2 trial compared the new weekly insulin, called icodec, to the commonly used i...

An immunotherapy drug significantly improved survival in patients with the most common type of bladder cancer, according to a new study.

About 550,000 new cases of bladder cancer are diagnosed worldwide each year, making it the 10th most common type of cancer, the study authors noted.

Chemotherapy is the initial standard of care for advanced bladder cancer. After chemotherap...

A new clinical trial will try to determine whether the measles, mumps and rubella (MMR) vaccine can protect health care workers from being infected with COVID-19.

Hundreds of millions of people have received the MMR vaccine since it was developed nearly 50 years ago. It's usually given to children before age 6. Growing evidence suggests that the vaccine may also prevent COVID-19.

...

An experimental treatment may help slow the progression of the deadly brain disease amyotrophic lateral sclerosis (ALS), a new study finds.

Researchers called the results a promising step in the fight against a devastating and invariably fatal disease. And two advocacy groups are calling for swift action to make the drug available to patients.

ALS is also known as Lou Gehrig...

A slew of "gold standard" clinical trials offer new hope for patients battling severe COVID-19: cheap, common drugs known as corticosteroids appear to cut the death rate by a third.

Publication of new data on treatment with corticosteroids such as hydrocortisone or dexamethasone "represents an important step forward in the treatment of patients with COVID-19," said Dr. Hallie Prescott...

An artificial pancreas system is safe and effective at managing blood sugar levels in kids as young as age 6 with type 1 diabetes, according to a new study.

The system uses a continuous glucose monitor (CGM) to track blood sugar levels and automatically delivers insulin when needed using an insulin pump. It replaces reliance on fingerstick or CGM with delivery of insulin by injection ...

There may be no cure for the common cold, but a spoonful of honey might make it less miserable, a new research review concludes.

Parents have long used honey to soothe kids' sore throats and cough -- probably because their parents did. But the review of 14 clinical trials finds some science to back it up.

Overall, adults and kids given honey had less-severe, less-frequent co...

While there are treatments to alleviate symptoms of Parkinson's disease, there is no known cure or preventive drug. But a recent review offers some encouraging findings.

The review found more than 100 clinical trials are underway around the world that are testing various preventive therapies and treatments for the neurodegenerative disorder.

The large number of trials, and ...

Although minorities are paying a disproportionate price in the rate of COVID-19 illnesses and deaths, they are underrepresented in clinical trials, a new study finds.

The researchers call upon the government, medical journals and funders of research to make sure trials include minorities so that the results can be extrapolated to the U.S. population.

In the Adaptive COVID-...

There is a longstanding fear in the scientific community that pharmaceutical companies could sway the research published in medical journals by paying them for advertising, but a new study reveals that advertising might not be the problem.

"All the available literature suggests that ad revenue should be the real concern, but that's not what we found," said study author S. Scott Graham...

A new injection drug can prevent multiple sclerosis flare-ups better than an existing medication, a clinical trial has found.

The drug, called ofatumumab, beat a standard MS medication in reducing patients' symptom relapses. It also slowed down the progression of their disability over six months.

The researchers said the findings, published Aug. 6 in the New England Journ...

The COVID-19 pandemic has prompted a massive scientific response to the crisis, with more than 1,500 coronavirus studies kicking off between March and mid-May of this year, a new study reports.

Unfortunately, much of this research has sown only confusion, producing precious little scientific evidence of sufficient quality to dramatically improve any understanding of COVID-19, research...

A cream medication that eases skin inflammation might offer a safer treatment option for people with psoriasis, a new clinical trial suggests.

Psoriasis is a chronic skin condition that affects more than 8 million Americans, according to the National Psoriasis Foundation. The disease arises from an abnormal immune response that triggers rapid turnover of skin cells, causing them to pi...

With several potential COVID-19 vaccines now in clinical trials, U.S. policymakers need to plan for the next hurdle: Ensuring Americans actually get vaccinated.

That's according to a new report from the Johns Hopkins Center for Health Security. It lays out recommendations for winning the public's trust of any future vaccine, and helping them access it as easily as possible.

...

A tuberculosis vaccine may help reduce the risk of death from COVID-19, researchers suggest.

Developing countries have lower-than-expected COVID-19 death rates, and a TB vaccine given in countries with high rates of tuberculosis might play a significant role in reducing COVID-19 death rates, according to authors of a new study.

The vaccine, which is routinely given to childr...

U.S. government-funded clinical trials for new cancer treatments have more Black participants than those run by drug companies, but Blacks are still underrepresented in cancer studies, researchers say.

The SWOG Cancer Research Network team analyzed data from 358 clinical trials -- 85 drug industry trials and 273 SWOG trials. They included nearly 94,000 patients who were being treated ...

There's more good news on the effectiveness of the antiviral drug remdesivir against COVID-19, according to new clinical trial results from the drug's maker.

Gilead Sciences said Friday that in a trial involving more than 1,100 patients, remdesivir was associated with improved recovery and a 62% reduced risk of death compared with standard care.

The study also showed tha...

Older, critically ill COVID-19 patients who are given a combination of two common antiretroviral drugs can experience a drastic slowing of their heart rate, French researchers report.

In their study of 41 patients treated with lopinavir and ritonavir twice daily for 10 days, 22% developed a slow heart rate condition called bradycardia. When the drugs were stopped or doses lowered,...

Older adults with healthy hearts probably would benefit from taking a cholesterol-lowering statin, a new study contends.

People 75 and older who were free of heart disease and prescribed a statin wound up with a 25% lower risk of death from any cause and a 20% lower risk of heart-related death, researchers reported July 7 in the Journal of the American Medical Association...

CT scans have been proven to help spot lung cancer early and save lives. Now, updated expert recommendations could double the number of Americans who are eligible for the yearly screening.

The recommendations -- from the U.S. Preventive Services Task Force (USPSTF) -- would expand the definition of "high risk" for lung cancer. That's expected to not only increase the number of people ...

An experimental ultrafast-acting insulin could work four times quicker than current fast-acting formulas, researchers say.

For the study, the researchers focused on a form of insulin called monomeric insulin. Though its structure should, in theory, allow it to act faster, monomeric insulin is too unstable for practical use, so the Stanford University team had to find a way around that...

Data from a five-year clinical trial is adding to growing evidence that deep brain stimulation (DBS) can slow the ravages of Parkinson's disease.

Researchers at Vanderbilt University Medical Center in Nashville, Tenn., said that the therapy appears to curb any worsening of tremor and other symptoms, as well as lessening a patient's need for medications.

"Parkinson's is relen...

There's new evidence that a 2,000-year-old medicine might offer hope against a modern scourge: COVID-19.

The medication, called colchicine, is an anti-inflammatory taken as a pill. It's long been prescribed for gout, a form of arthritis, and its history goes back centuries. The drug was first sourced from the autumn crocus flower.

Doctors also sometimes use colchicine to tre...

An inhaled version of the antiviral drug remdesivir will soon be tested outside a hospital setting, Gilead Sciences announced Monday.

Remdesivir, which is made by Gilead, is now being used to treat COVID-19 patients worldwide. Currently, the drug has to be given intravenously through daily infusions in the hospital.

"An inhaled formulation would be given through a nebulizer...

In a new trial there are hints, but no proof, that a wriggling intestinal parasite might help fight multiple sclerosis.

The lowly hookworm has for years been proposed as a potential treatment for multiple sclerosis (MS) and other autoimmune disorders.

But the first clinical trial testing the potential benefits of the parasite against MS has produced decidedly mixed results, ...

Your sex matters when it comes to your health, yet women may still be an afterthought in research studies.

Despite policies and grant requirements to include females in research studies, many researchers still don't analyze their data by sex, a new study found. If researchers don't look at their results by sex, it's impossible to know if diseases, drugs or vaccines might impact each ...

Hydroxychloroquine, the malaria drug touted and reportedly used by President Donald Trump as a preventative for COVID-19, appears not to have lived up to its hype, a new study shows.

Unlike some prior studies, this new trial was a "gold standard" prospective, randomized clinical trial. It found that hydroxychloroquine could not prevent COVID-19 any better than a sugar pill.

...

Intensive high blood pressure treatment may protect against a-fib, a heart rhythm disorder that can lead to stroke, heart attack and heart failure, researchers say.

They analyzed data from more than 8,000 high blood pressure patients who were at increased risk of heart disease and enrolled in a U.S. National Institutes of Health trial known as SPRINT.

Participants were on e...

In the race to find treatments for COVID-19, the antiviral drug remdesivir has gotten much of the attention. But researchers say a class of long-used drugs called interferons also looks promising.

Trials testing the medications are underway in several countries. A small study published last week in The Lancet found that a three-drug regimen, containing an interferon, helped hos...

A combination of chemotherapy and immunotherapy may slow the progress of metastatic bladder cancer and extend survival, a clinical trial suggests.

Current treatment for advanced bladder cancer is chemotherapy, but adding the immunotherapy drug atezolizumab (Tecentriq) appears to help more patients fight this disease. It strikes 81,000 Americans a year and kills 18,000.

"Th...

There's been much speculation about whether vitamin D might prevent or help survival with COVID-19, and two new studies appear to underscore the link.

In the first study -- published in the journal Aging Clinical and Experimental Research -- British researchers found that COVID-19 infections and deaths were higher in countries where people had low vitamin D levels, such as Ita...

In the scramble to find medicines that beat back COVID-19, researchers from Italy report encouraging results from a small study on a rheumatoid arthritis drug already in use.

The drug, anakinra, may help quiet the runaway immune response known as a "cytokine storm," which imperils some patients with severe COVID-19.

"Until a vaccine is available, we urgently need to find a w...

There's been a sharp decline in the number of U.S. children taking part in cancer clinical trials over the past few decades, but researchers say that might be good news.

Why? Having more effective treatments available now may be one reason for that decrease, they explained.

The researchers, from the University of Colorado Cancer Center, analyzed national data and found that ...

Researchers have reformulated an HIV medication into a version they hope can eventually be taken as infrequently as once a year.

The work is only in the early stages, having been studied in lab animals. But the goal is to create an HIV drug that can be injected annually -- offering protection from infection or control of the virus in people who already have it.

The researche...

A new oral polio vaccine promises to help make polio a disease of the past, according to the results of a phase 1 clinical trial.

Polio was almost eliminated worldwide -- except in vaccine-induced cases. In those cases, the weakened virus used in vaccines developed the ability to escape from immunized individuals and spread in places with low vaccination rates.

The new des...

Dozens of drugs are being investigated for their value in treating COVID-19, as desperation drives doctors and researchers to look for something that could battle the virus and save lives.

"There are really no FDA-approved medications for the treatment of COVID-19, unfortunately," said Ashley Barlow, a pharmacy resident with the University of Maryland Medical Center in Baltimore. "We'...

As researchers hunt for ways to treat severe COVID-19 infections, a new trial will ask whether an old arthritis drug can prevent serious complications in the first place.

The medication, called colchicine, is an oral anti-inflammatory that has long been prescribed for gout, a form of arthritis. Its history goes back thousands of years, and the drug was first sourced from the autumn cr...

Preliminary data from two clinical trials using the antiviral drug remdesivir to treat COVID-19 patients is encouraging, researchers report.

One trial is providing the drug to patients with moderate illness and the other focuses on patients with severe illness.

A number of the patients are now recovering and have been released from the hospital. While it's too early to tell...

Doctors at the University of Alabama at Birmingham (UAB) are enrolling patients in an international clinical trial to find out if inhaled nitric oxide benefits those with COVID-19 who have severely damaged lungs.

Right now, there are no approved treatments for the illness caused by the new coronavirus. A severe form of lung failure called acute respiratory distress syndrome is the lea...

Intensifying a standard form of brain stimulation may bring relief to people with hard-to-treat depression, a preliminary study suggests.

The study involved just 21 patients, but the treatment sent 90% into remission within a few days. That's a success rate that has never been seen in early testing of other therapies for severe depression, the researchers said.

The thera...

A drug originally developed to treat Ebola is getting a second chance in the spotlight, as research teams in the United States, Asia and Europe race to test it against the new coronavirus.

The drug, called remdesivir, has already been given to a limited number of patients hospitalized with COVID-19, on a "compassionate use" basis. That included the first U.S. patient diagnosed with th...

The first community-acquired case of COVID-19 in the United States posed many questions for doctors, but the answers they found led to key changes in federal guidelines for coronavirus testing, according to a case study.

The patient was an otherwise healthy woman in her 40s who was admitted to University of California (UC) Davis Health with a respiratory infection. Doctors suspected c...